insights from the coding and non-coding transcriptomes

"In a context of increasing wood demand from the forest industry worldwide, maritime pine (Pinus pinaster) breeding programs have been putting their focus on wood traits, resilience to abiotic stresses and to biotic agents. Ultimately, one of the main goals is to produce large numbers of clonal trees from the ones selected with the improved traits. Currently, the clonal propagation of the genotypes selected in breeding programs is already being applied to several forest tree species for commercial purposes, namely by using a type of vegetative propagation technology called somatic embryogenesis. P. pinaster is not yet among the forest tree species which have been successfully clonally propagated on a large commercial scale by somatic embryogenesis.(...)

A aprendizagem da matemática fora da sala de aula

Relatório de Prática de Ensino Supervisionada apresentado à Escola Superior de Educação de Lisboa para obtenção de grau de mestre em Ensino do 1.º Ciclo do Ensino Básico e de Matemática e Ciências Naturais no 2.º Ciclo do Ensino BásicoO presente relatório foi desenvolvido no âmbito da Unidade Curricular de Prática de Ensino Supervisionada II, do Mestrado em Ensino do 1.º Ciclo do Ensino Básico (CEB) e de Matemática e Ciências Naturais no 2.º CEB. A investigação que se apresenta, subordinada ao tema “A aprendizagem da Matemática fora da sala de aula” teve como objetivo compreender o contributo das atividades realizadas fora da sala de aula para a aprendizagem significativa da matemática, por parte de alunos do 1º CEB, tendo sido formuladas as seguintes questões: (i) De que modo os alunos reconhecem a matemática nas atividades realizadas fora da sala de aula?; (ii) Como é que as atividades desenvolvidas fora da sala de aula contribuem para a compreensão pelos alunos dos conteúdos matemáticos abordados?. A metodologia utilizada foi de natureza qualitativa interpretativa, tendo como técnicas de recolha de dados a observação direta e participante, a entrevista focus group e a recolha documental e como instrumentos os registos dos alunos, as notas de campo, a gravação áudio da entrevista e os registos fotográficos. Os resultados do estudo demonstraram que as atividades realizadas fora da sala de aula contribuem para uma aprendizagem significativa da matemática, levando os alunos ao reconhecimento da matemática no mundo que os rodeia e à compreensão dos conteúdos matemáticos através do contacto experiencial.The present report is developed within the scope of the Curricular Unit of Supervised Teaching Practice II, of the Master's in Teaching of the 1st Cycle of Basic Education (CEB) and of Mathematics and Natural Sciences in the 2nd CEB. The investigation that is presented, subordinated to the theme "The learning of mathematics outside the classroom", had as objective to understand the contribution the activities performed outside the classroom for significative learning of mathematics, by students of the 1st CEB. The following questions were formulated: (i) How do students recognize mathematics in activities outside the classroom?; (ii) How do the activities developed outside the classroom contribute to the students' understanding of the mathematical contents covered?. The methodology used had an interpretive qualitative nature,. It was used the following data collection techniques: direct and participant observation, interview focus group and documentary collection.The data collection instruments were student records, field notes, audio recording of the interview and photographic records. The results of the study showed that the activities performed outside the classroom contribute to meaningful learning of mathematics, leading students to recognition of mathematics in the world that surrounds them and to understanding of mathematical content through experiential contact.N/

Influence of wearing an unstable shoe on thigh and leg muscle activity and venous response in upright standing

Purpose: To quantify the effect of unstable shoe wearing on muscle activity and haemodynamic response during standing. Methods: Thirty volunteers were divided into 2 groups: the experimental group wore an unstable shoe for 8 weeks, while the control group used a conventional shoe for the same period. Muscle activity of the medial gastrocnemius, tibialis anterior, rectus femoris and biceps femoris and venous circulation were assessed in quiet standing with the unstable shoe and barefoot. Results: In the first measurement there was an increase in medial gastrocnemius activity in all volunteers while wearing the unstable shoe. On the other hand, after wearing the unstable shoe for eight weeks these differences were not verified. Venous return increased in subjects wearing the unstable shoe before and after training. Conclusions: The unstable shoe produced changes in electromyographic characteristics which were advantageous for venous circulation even after training accommodation by the neuromuscular system

Comment l'infirmière peut-elle contribuer au respect des choix et perspectives d'une personne en situation palliative atteinte d'un cancer: travail de Bachelor

But : Ce travail aborde la manière avec laquelle les infirmières1 accompagnent des personnes atteintes d’un cancer avancé, dans un contexte de soins palliatifs en tenant compte du respect de leurs choix et perspectives, afin que ceux-ci soient respectés, en préservant leur dignité et leur liberté de choix. Le cadre théorique s’appuie sur le paradigme de l’humaindevenant de Rosemarie Rizzo Parse. Cette théoricienne insiste sur l’importance de comprendre et de connaître les valeurs et les intentions de chaque personne afin de pouvoir respecter la dignité de chaque être humain. Méthode : La recherche s’est effectuée par l’élaboration du PICOT de la problématique, ainsi que de mots clés permettant le questionnement des bases de données. Suite à cela, les recherches ont permis d’avoir divers articles scientifiques. Ces derniers ont été lus afin de sélectionner ceux répondant pour le mieux aux divers critères, permettant ainsi une analyse d’articles pertinente au sujet du travail. Neufs articles ont été sélectionnés entre avril et juin 2017 à l’aide de deux moteurs de recherche, PubMed et Cinahl

The potencial role of soil application of a tris (3-hydroxy-4-pyridinonate) iron (III) complex in iron deficiency chlorosis treatment

info:eu-repo/semantics/publishedVersio

Burnout, resilience, and subjective well-being among Portuguese lecturers’ during the COVID-19 pandemic

Background: Lecturers face a large wide of occupational stressors. If the prolonged stress and the symptomatology associated with the working conditions to which lecturers were exposed were already a concern before the pandemic, the pandemic may have exacerbated this psychosocial vulnerability. Burnout is a psychological syndrome that develops in response to chronic work stress. This study aims to describe burnout amongst lecturers working in Portugal and to analyse potential determinants of burnout during the COVID-19 pandemic. Methods: A cross-sectional study was performed using an online questionnaire distributed via social networks. The survey collected sociodemographic and sleep patterns data in addition to applying the Copenhagen Burnout Inventory (personal, work- and student-related burnout), the Resilience Scale, the Depression Anxiety and Stress Scales, and the Satisfaction with Life Scale. Results: The sample included 331 lecturers from 35 different colleges and faculties. Three significant models explained personal (R2 = 54%), work- (R2 = 47%) and student- (R2 = 19%) related burnout. Lower levels of resilience and higher levels of depression and stress were significantly associated with personal and work-related burnout. Changes in sleep patterns were additionally associated with both personal and work-related burnout. Conclusion: Higher education institutions must recognize the impact of the work environment and organizational culture on faculty mental health and take proactive measures to improve this environment. These institutions can implement support strategies such as educational technology training, professional development programmes, emotional support resources, and workload flexibility. Implementing measures to enhance lecturers’ resilience and overall life satisfaction could potentially help mitigate burnout and improve the well-being of educators, ultimately contributing to the overall quality of education.info:eu-repo/semantics/publishedVersio

Genetic information improves the prediction of major adverse cardiovascular events in the GENEMACOR population

The inclusion of a genetic risk score (GRS) can modify the risk prediction of coronary artery disease (CAD), providing an advantage over the use of traditional models. The predictive value of the genetic information on the recurrence of major adverse cardiovascular events (MACE) remains controversial. A total of 33 genetic variants previously associated with CAD were genotyped in 1587 CAD patients from the GENEMACOR study. Of these, 18 variants presented an hazard ratio >1, so they were selected to construct a weighted GRS (wGRS). MACE discrimination and reclassification were evaluated by C-Statistic, Net Reclassification Index and Integrated Discrimination Improvement methodologies. After the addition of wGRS to traditional predictors, the C-index increased from 0.566 to 0.572 (p=0.0003). Subsequently, adding wGRS to traditional plus clinical risk factors, this model slightly improved from 0.620 to 0.622 but with statistical significance (p=0.004). NRI showed that 17.9% of the cohort was better reclassified when the primary model was associated with wGRS. The Kaplan-Meier estimator showed that, at 15-year follow-up, the group with a higher number of risk alleles had a significantly higher MACE occurrence (p=0.011). In CAD patients, wGRS improved MACE risk prediction, discrimination and reclassification over the conventional factors, providing better cost-effective therapeutic strategies.info:eu-repo/semantics/publishedVersio

Impact of genetic information on Coronary Disease risk in Madeira: The GENEMACOR study

Copyright © 2022. Publicado por Elsevier España, S.L.U.The Publisher regrets that this article is an accidental duplication of an article that has already been published, 10.1016/j.repc.2022.10.005. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.proofepub_ahead_of_prin

The GENEMACOR study

Copyright © 2022 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.INTRODUCTION: Coronary artery disease (CAD), characterized by an atherogenic process in the coronary arteries, is one of the leading causes of death in Madeira. The GENEMACOR (GENEs in MAdeira and CORonary Disease) study sought to investigate the main risk factors - environmental and genetic - and estimate whether a genetic risk score (GRS) improves CAD prediction, discrimination and reclassification. METHODS: Traditional risk factors and 33 CAD genetic variants were considered in a case-control study with 3139 individuals (1723 patients and 1416 controls). The multivariate analysis assessed the likelihood of CAD. A multiplicative GRS (mGRS) was created, and two models (with and without mGRS) were prepared. Two areas under receiver operating characteristic curve (area under curve (AUC)) were analyzed and compared to discriminate CAD likelihood. Net reclassification improvement (NRI) and integrated discrimination index (IDI) were used to reclassify the population. RESULTS: All traditional risk factors were strong and independent predictors of CAD, with smoking being the most significant (OR 3.25; p<0.0001). LPA rs3798220 showed a higher CAD likelihood (odds ratio 1.45; p<0.0001). Individuals in the fourth mGRS quartile had an increased CAD probability of 136% (p<0.0001). A traditional risk factor-based model estimated an AUC of 0.73, rising to 0.75 after mGRS inclusion (p<0.0001), revealing a better fit. Continuous NRI better reclassified 28.1% of the population, and categorical NRI mainly improved the reclassification of the intermediate risk group. CONCLUSIONS: CAD likelihood was influenced by traditional risk factors and genetic variants. Incorporating GRS into the traditional model improved CAD predictive capacity, discrimination and reclassification. These approaches may provide helpful diagnostic and therapeutic advances, especially in the intermediate risk group.publishersversionpublishe